Atanes A, Gómez N, Aspe B, de Toro J, Graña J, Sánchez J M, Galdo F
Unidad de Reumatología, Hospital Juan Canalejo, La Coruña.
Med Clin (Barc). 1991 Feb 9;96(5):169-72.
We have evaluated 160 patients diagnosed of erythema nodosum (EN) on the basis of clinical and/or histopathological criteria to assess their etiology and their major epidemiological, clinical and laboratory features in our area. Mean age was 37.5 years and 86% of patients were females. The etiology could be determined in 67.5% of cases: sarcoidosis (20.6%), drugs (18%), streptococcal infection (16.3%), tuberculosis (6.3%), pregnancy (1.9%), Crohn's disease (1.3%), Behçet's disease (1.3%), lymphoma (0.6%), adenocarcinoma (0.6%), and toxoplasmosis (0.6%). 32.5% of cases were idiopathic. We found significant differences between the different etiological factors regarding mean age, fever, joint disease, ESR, leukocytosis and serum proteins. We compare our results with those from other series and we emphasize the need for a systematic workup in all patients with EN to facilitate their etiological diagnosis.
我们根据临床和/或组织病理学标准，对160例诊断为结节性红斑（EN）的患者进行了评估，以确定其病因以及我们地区主要的流行病学、临床和实验室特征。平均年龄为37.5岁，86%的患者为女性。67.5%的病例可确定病因：结节病（20.6%）、药物（18%）、链球菌感染（16.3%）、结核病（6.3%）、妊娠（1.9%）、克罗恩病（1.3%）、白塞病（1.3%）、淋巴瘤（0.6%）、腺癌（0.6%）和弓形虫病（0.6%）。32.5%的病例病因不明。我们发现不同病因因素在平均年龄、发热、关节疾病、红细胞沉降率、白细胞增多和血清蛋白方面存在显著差异。我们将我们的结果与其他系列研究的结果进行了比较，并强调对所有结节性红斑患者进行系统检查以促进其病因诊断的必要性。
