• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

类风湿关节炎伴结节性红斑酷似蜂窝织炎的非典型表现：一例报告及结节性红斑文献综述

Atypical Presentation of Rheumatoid Arthritis With Erythema Nodosum Mimicking Cellulitis: A Case Report and Literature Review of Erythema Nodosum.

作者信息

Wagle Laxman, Basnyat Parmartha, Timshina Anuj, Regmi Rashmita

机构信息

Department of Internal Medicine Ascension Saint Agnes Hospital Baltimore Maryland USA.

Department of Internal Medicine Patan Academy of Health Science Kathmandu Nepal.

出版信息

Clin Case Rep. 2025 Jun 2;13(6):e70566. doi: 10.1002/ccr3.70566. eCollection 2025 Jun.

DOI:10.1002/ccr3.70566
PMID:40463736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12129819/
Abstract

Erythema nodosum (EN) can be an atypical manifestation of rheumatoid arthritis (RA), as seen in this case of a 35-year-old woman initially misdiagnosed with cellulitis. Despite negative cultures and antibiotic treatment, further evaluation revealed elevated rheumatoid factor and anti-CCP antibodies, confirming RA. Steroids led to symptom resolution.

摘要

结节性红斑（EN）可能是类风湿关节炎（RA）的一种非典型表现，就像本例中一名35岁女性最初被误诊为蜂窝织炎那样。尽管培养结果为阴性且接受了抗生素治疗，但进一步评估发现类风湿因子和抗环瓜氨酸肽抗体升高，从而确诊为RA。使用类固醇后症状得到缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/e6aef4eb0253/CCR3-13-e70566-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/6402cb5a1ea4/CCR3-13-e70566-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/3b1fbc9d12be/CCR3-13-e70566-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/bc4fb2ec252b/CCR3-13-e70566-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/e6aef4eb0253/CCR3-13-e70566-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/6402cb5a1ea4/CCR3-13-e70566-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/3b1fbc9d12be/CCR3-13-e70566-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/bc4fb2ec252b/CCR3-13-e70566-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cee5/12129819/e6aef4eb0253/CCR3-13-e70566-g001.jpg

相似文献

1
Atypical Presentation of Rheumatoid Arthritis With Erythema Nodosum Mimicking Cellulitis: A Case Report and Literature Review of Erythema Nodosum.类风湿关节炎伴结节性红斑酷似蜂窝织炎的非典型表现：一例报告及结节性红斑文献综述
Clin Case Rep. 2025 Jun 2;13(6):e70566. doi: 10.1002/ccr3.70566. eCollection 2025 Jun.
2
Miescher's radial granuloma. A characteristic marker of erythema nodosum.米舍尔氏结节性肉芽肿。结节性红斑的特征性标志物。
Am J Dermatopathol. 1989 Oct;11(5):434-42. doi: 10.1097/00000372-198910000-00005.
3
[Erythema nodosum leprosum and Miescher's radiate granuloma].[结节性红斑样麻风与米舍尔放射状肉芽肿]
Rev Bras Leprol. 1962 Jan-Jun;30:69-72.
4
Miescher's granulomas in erythema nodosum.结节性红斑中的米舍尔肉芽肿。
Dermatologica. 1950;101(2):80-4.
5
Atypical Presentation of Erythema Nodosum Following Pfizer-BioNTech COVID-19 Vaccine.辉瑞-生物科技公司新冠疫苗接种后结节性红斑的非典型表现
Med Arch. 2022 Feb;76(1):72-74. doi: 10.5455/medarh.2022.76.72-74.
6
Impact of Cyclic Citrullinated Peptide Antibody Level on Progression to Rheumatoid Arthritis in Clinically Tested Cyclic Citrullinated Peptide Antibody-Positive Patients Without Rheumatoid Arthritis.在临床检测到循环瓜氨酸肽抗体阳性但没有类风湿关节炎的患者中，循环瓜氨酸肽抗体水平对进展为类风湿关节炎的影响。
Arthritis Care Res (Hoboken). 2019 Dec;71(12):1583-1592. doi: 10.1002/acr.23820.
7
Clinical diagnostic significance of 14-3-3η protein, high-mobility group box-1, anti-cyclic citrullinated peptide antibodies, anti-mutated citrullinated vimentin antibodies and rheumatoid factor in rheumatoid arthritis.14-3-3η蛋白、高迁移率族蛋白B1、抗环瓜氨酸肽抗体、抗突变瓜氨酸波形蛋白抗体及类风湿因子在类风湿关节炎中的临床诊断意义
Br J Biomed Sci. 2020 Jan;77(1):19-23. doi: 10.1080/09674845.2019.1658425. Epub 2019 Sep 16.
8
Granulomatous mastitis, erythema nodosum and arthritis syndrome: case-based review.肉芽肿性乳腺炎、结节性红斑和关节炎综合征：基于病例的综述。
Rheumatol Int. 2021 Jun;41(6):1175-1181. doi: 10.1007/s00296-021-04820-8. Epub 2021 Mar 1.
9
Determination of anti-cyclic citrullinated peptide antibodies in the sera of patients with juvenile idiopathic arthritis.青少年特发性关节炎患者血清中抗环瓜氨酸肽抗体的测定。
J Rheumatol. 2004 Sep;31(9):1829-33.
10
Pembrolizumab-associated erythema nodosum in the treatment of metastatic melanoma.帕博丽珠单抗治疗转移性黑色素瘤相关的结节性红斑。
Immunotherapy. 2022 Sep;14(13):1021-1026. doi: 10.2217/imt-2021-0239. Epub 2022 Jul 27.

本文引用的文献

1
Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment.类风湿关节炎的皮肤表现：诊断与治疗
J Pers Med. 2023 Oct 10;13(10):1479. doi: 10.3390/jpm13101479.
2
Initial presentation of early rheumatoid arthritis.早期类风湿关节炎的初始表现。
PLoS One. 2023 Jul 6;18(7):e0287707. doi: 10.1371/journal.pone.0287707. eCollection 2023.
3
A challenging case of rheumatoid arthritis-associated aortitis presenting with erythema nodosum after ST-segment elevation myocardial infarction: A case report.1例类风湿关节炎相关性主动脉炎在ST段抬高型心肌梗死后出现结节性红斑的具有挑战性病例：病例报告
Clin Case Rep. 2022 Nov 12;10(11):e6402. doi: 10.1002/ccr3.6402. eCollection 2022 Nov.
4
Rheumatoid arthritis: Extra-articular manifestations and comorbidities.类风湿关节炎：关节外表现及合并症
Autoimmun Rev. 2021 Apr;20(4):102776. doi: 10.1016/j.autrev.2021.102776. Epub 2021 Feb 17.
5
Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017.全球、地区和国家类风湿关节炎负担 1990-2017 年：2017 年全球疾病负担研究的系统分析。
Ann Rheum Dis. 2019 Nov;78(11):1463-1471. doi: 10.1136/annrheumdis-2019-215920. Epub 2019 Sep 11.
6
Skin manifestations of rheumatoid arthritis.类风湿关节炎的皮肤表现
G Ital Dermatol Venereol. 2018 Apr;153(2):243-255. doi: 10.23736/S0392-0488.18.05872-8. Epub 2018 Jan 24.
7
Cellulitis: A Review.蜂窝织炎：综述。
JAMA. 2016 Jul 19;316(3):325-37. doi: 10.1001/jama.2016.8825.
8
Diagnostic performance of anti-cyclic citrullinated peptide and rheumatoid factor in patients with rheumatoid arthritis.抗环瓜氨酸肽和类风湿因子在类风湿关节炎患者中的诊断效能
Int J Rheum Dis. 2016 Sep;19(9):880-6. doi: 10.1111/1756-185X.12552. Epub 2015 May 4.
9
[Löfgren syndrome: a study of 80 cases].[结节病综合征：80例病例研究]
Med Clin (Barc). 2014 Aug 19;143(4):166-9. doi: 10.1016/j.medcli.2014.02.029. Epub 2014 May 22.
10
Erythema nodosum - a review of an uncommon panniculitis.结节性红斑——一种罕见脂膜炎的综述
Dermatol Online J. 2014 Apr 16;20(4):22376.