Takahashi Atsushi, Shiga Tsuyoshi, Shoda Morio, Tanizaki Kohei, Manaka Tetsuyuki, Ejima Koichiro, Kasanuki Hiroshi, Hagiwara Nobuhisa
Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Heart Vessels. 2010 Mar;25(2):150-4. doi: 10.1007/s00380-009-1181-y. Epub 2010 Mar 26.
Previous studies indicated that women were less likely to experience ventricular arrhythmia recurrence than men among patients with coronary artery disease and implantable cardioverter defibrillator (ICD). However, it is not clear whether the risk for ventricular tachyarrhythmia is gender-dependent in patients with nonischemic dilated cardiomyopathy. This study included 173 consecutive nonischemic dilated cardiomyopathy patients with a left ventricular ejection fraction of <45% (122 men and 51 women), who received ICD therapy between 1990 and 2008. The average follow-up period was 33 +/- 28 months. There was no significant difference in event-free rates of appropriate ICD therapy between genders for all patients (P = 0.15) and by indication of ICD (primary prevention: P = 0.43, secondary prevention: P = 0.24). There was also no significant difference in event-free rates of electrical storm between genders (P = 0.17). In high-risk patients with nonischemic dilated cardiomyopathy who received ICD, there was no gender difference in the incidence of appropriate ICD therapy or electrical storm.
先前的研究表明，在患有冠状动脉疾病且植入了植入式心律转复除颤器（ICD）的患者中，女性发生室性心律失常复发的可能性低于男性。然而，尚不清楚在非缺血性扩张型心肌病患者中，室性快速心律失常的风险是否存在性别差异。本研究纳入了1990年至2008年间接受ICD治疗的173例连续的左心室射血分数<45%的非缺血性扩张型心肌病患者（122例男性和51例女性）。平均随访期为33±28个月。所有患者以及根据ICD适应证（一级预防：P = 0.43，二级预防：P = 0.24）分类的患者中，两性之间适当ICD治疗的无事件发生率无显著差异（P = 0.15）。两性之间电风暴的无事件发生率也无显著差异（P = 0.17）。在接受ICD治疗的非缺血性扩张型心肌病高危患者中，适当ICD治疗或电风暴的发生率不存在性别差异。
