The evaluation of solution- and solid-phase approaches to the divergent synthesis cinnoline and phenanthrene ring systems: SCS-09 special issue-combinatorial approaches to discovery.

Cinnoline and phenanthrene ring systems have been synthesized from a set of readily available substrates using functional group tolerant reactions. This approach proved successful in both solution- and solid-phase synthesis for phenanthrenes but was limited to solution-phase synthesis for cinnolines. The described approaches to these ring systems complements related approaches to other scaffolds that can be readily accessed from the same substrates using slight variations in the applied chemistry.