Kamal Ahmed, Reddy K Laxma, Devaiah V, Shankaraiah N, Rao M V
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India.
Mini Rev Med Chem. 2006 Jan;6(1):71-89. doi: 10.2174/138955706775197839.
Quinoxaline, quinazoline and benzimidazole based templates have been synthesized on solid-support employing different methodologies. This review enlightens academic and industrial examples of combinatorial synthesis for this type of heterocycles that appeared in the literature in the last decade. Hence, some of the important synthetic strategies for the generation of quinoxaline, quinazoline and benzimidazole based privileged structures, and the important biological activities for these heterocycles have been highlighted. Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review.
基于喹喔啉、喹唑啉和苯并咪唑的模板已采用不同方法在固体载体上合成。本综述阐述了过去十年文献中出现的这类杂环组合合成的学术和工业实例。因此，重点介绍了一些用于生成基于喹喔啉、喹唑啉和苯并咪唑的优势结构的重要合成策略，以及这些杂环的重要生物活性。此外，本综述还研究了苯并噻二嗪酮、硫代喹唑啉酮、噌啉和吲唑。
