一个DNA复制基因定位于大肠杆菌K12的terC附近。
A DNA replication gene maps near terC in Escherichia coli K12.
作者信息
Ben-Neria T, Ron E Z
机构信息
Department of Microbiology, George S. Wise Faculty of Life Science, Tel-Aviv University, Israel.
出版信息
Mol Gen Genet. 1991 Apr;226(1-2):315-7. doi: 10.1007/BF00273619.
PMID:2034225
Abstract
Temperature-sensitive mutants that filamented at the non-permissive temperature were isolated by specific mutagenesis of the terminus region of the Escherichia coli chromosome. Two of them, mapping at about 35 min, failed to divide due to inhibition of DNA replication. Further characterization indicated that these mutants are temperature-sensitive for DNA chain elongation.
摘要
通过对大肠杆菌染色体末端区域进行特异性诱变，分离出了在非允许温度下形成丝状体的温度敏感突变体。其中两个位于约35分钟处，由于DNA复制受到抑制而无法分裂。进一步的表征表明，这些突变体对DNA链延伸具有温度敏感性。
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