[Ectopic production of chorionic gonadotropin in apudomas (author's transl)].
作者信息
Seif F J, Scherbaum W, Sadowski P, Heni F, Kruz-Isler G
出版信息
Dtsch Med Wochenschr. 1978 Feb 10;103(6):253-4, 257-9. doi: 10.1055/s-0028-1104417.
PMID:203438
Abstract
Two pheochromocytomas, two carcinoid tumours of the ileum and one pancreatic vipoma showed APUD-system properties and formed electron-dense secretory granules indicating synthesis and storage of proteohormones. Besides catecholamines, 5-hydroxytryptamine and vasoactive intestinal polypeptide, all five tumours contained immunoreactive chorionic gonadotropin and also its free, protomeric beta chain as a sign of de-differentiation. Plasma of the tumour patients also contained immunoreactive chorionic gonadotropin and the free protomeric beta chain, both of which are useful tumour markers.
摘要
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