马拉维儿童轮状病毒研究史：对一种致命病毒的探索
History of rotavirus research in children in Malawi: the pursuit of a killer.
作者信息
Cunliffe Nigel, Wittel Desiree, Ngwira Bagrey
机构信息
Division of Medical Microbiology, School of Infection and Host Defence, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK.
出版信息
Malawi Med J. 2009 Sep;21(3):113-5. doi: 10.4314/mmj.v21i3.45631.
Rotavirus gastroenteritis is a major health problem among Malawian children. Studies spanning 20 years have described the importance, epidemiology and viral characteristics of rotavirus infections in the country. Despite a wide diversity of circulating rotavirus strains causing severe disease in young infants, a clinical trial of a human rotavirus vaccine clearly demonstrated the potential for rotavirus vaccination to greatly reduce the morbidity and mortality due to rotavirus diarrhoea in Malawi. This new enteric vaccine initiative represents a major opportunity to improve the health and survival of Malawian children.
轮状病毒肠胃炎是马拉维儿童面临的一个主要健康问题。长达20年的研究描述了该国轮状病毒感染的重要性、流行病学及病毒特征。尽管在该国导致幼儿严重疾病的轮状病毒株种类繁多，但一项人类轮状病毒疫苗临床试验清楚地表明，轮状病毒疫苗接种有潜力大幅降低马拉维因轮状病毒腹泻导致的发病率和死亡率。这项新的肠道疫苗倡议是改善马拉维儿童健康和生存状况的一个重大契机。
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