Departments of Pediatrics and Neonatology, Medical University Vienna, Vienna, Austria.
Epilepsia. 2010 Jun;51(6):1086-9. doi: 10.1111/j.1528-1167.2010.02543.x. Epub 2010 Mar 18.
Diabetes type 1 seems to be more prevalent in epilepsy, and low-carbohydrate diets improve glycemic control in diabetes type 2, but data on the use of the classic ketogenic diet (KD) in epilepsy and diabetes are scarce. We present 15 months of follow-up of a 3 years and 6 months old girl with diabetes type 1 (on the KD), right-sided hemiparesis, and focal epilepsy due to a malformation of cortical development. Although epileptiform activity on electroencephalography (EEG) persisted (especially during sleep), clinically overt seizures have not been reported since the KD. An improved activity level and significant developmental achievements were noticed. Glycosylated hemoglobin (HbA1c) levels improved, and glycemic control was excellent, without severe side effects. Our experience indicates that diabetes does not preclude the use of the KD.
1 型糖尿病似乎在癫痫中更为普遍，低碳水化合物饮食可改善 2 型糖尿病的血糖控制，但关于经典生酮饮食 (KD) 在癫痫和糖尿病中的应用的数据却很少。我们报告了一名 3 岁 6 个月大的女孩的 15 个月随访结果，她患有 1 型糖尿病（接受 KD 治疗）、右侧偏瘫和局灶性癫痫，病因是皮质发育畸形。尽管脑电图 (EEG) 上的癫痫样活动持续存在（尤其是在睡眠期间），但自接受 KD 以来，并未报告出现临床明显的癫痫发作。注意到活动水平提高，并且取得了显著的发育成就。糖化血红蛋白 (HbA1c) 水平改善，血糖控制非常好，且没有严重的副作用。我们的经验表明，糖尿病并不妨碍 KD 的使用。
