Section Hepatobiliairy Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Am J Transplant. 2010 Jun;10(6):1349-53. doi: 10.1111/j.1600-6143.2010.03064.x. Epub 2010 Mar 19.
The Model for End-Stage Liver Disease (MELD) score is widely used to prioritize patients for liver transplantation. One of the pitfalls of the MELD score is the interlaboratory variability in all three components of the score (INR, bilirubin, creatinine). The interlaboratory variability in the INR has the largest impact on the MELD score, with a mean difference of around 5 MELD points in most studies. During the 3rd conference on Coagulopathy and Liver disease, a multidisciplinary group of scientists and physicians discussed possible solutions for the INR problem in the MELD score with the intention to provide a constructive contribution to the international debate on this issue. Here we will discuss possible solutions and highlight advantages and disadvantages.
终末期肝病模型（MELD）评分被广泛用于对肝移植患者进行优先排序。MELD 评分的一个缺陷是评分的三个组成部分（INR、胆红素、肌酐）在实验室间存在差异。INR 在实验室间的差异对 MELD 评分的影响最大，在大多数研究中平均差异约为 5 个 MELD 点。在第三届凝血障碍和肝病会议上，一个由科学家和医生组成的多学科小组讨论了 MELD 评分中 INR 问题的可能解决方案，旨在为这一问题的国际辩论做出建设性的贡献。在这里，我们将讨论可能的解决方案，并强调其优缺点。
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