Leibniz Institute for Age Research - Fritz-Lipmann-Institute, Jena, Germany.
J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):69-75. doi: 10.1016/j.jsbmb.2010.03.058. Epub 2010 Mar 24.
Glucocorticoids are potent immunosuppressive agents with complex actions on immune cells evoking the following effects: inducing apoptosis, changing differentiation fate, inhibition of cytokine release, inhibition of migration and other features. Distinct molecular mechanisms of the glucocorticoid receptor (GR) contribute to different anti-inflammatory effects. Recently inflammatory models have been investigated using conditional knockout and function selective mice shedding light on critical cell types and molecular mechanisms of endogenous and therapeutic GC actions. Here we review the multiple effects of GCs on major immune cells, dendritic cells, myeloid cells and B- and T-lymphocytes and give a summary of studies using conditional GR knockout mice.
糖皮质激素是具有复杂免疫作用的强效免疫抑制剂，可对免疫细胞产生以下作用：诱导细胞凋亡、改变分化命运、抑制细胞因子释放、抑制迁移等。糖皮质激素受体（GR）的不同分子机制导致不同的抗炎作用。最近，使用条件性基因敲除和功能选择性小鼠研究了炎症模型，阐明了内源性和治疗性 GC 作用的关键细胞类型和分子机制。本文综述了 GC 对主要免疫细胞（树突状细胞、髓样细胞和 B 淋巴细胞和 T 淋巴细胞）的多种作用，并对使用条件性 GR 基因敲除小鼠的研究进行了总结。
