麦冬根中的高异黄酮衍生物及其体外抗炎活性。

Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity.

作者信息

Hung Tran Manh, Thu Cao Van, Dat Nguyen Tien, Ryoo Sung-Woo, Lee Jeong Hyung, Kim Jin Cheol, Na Minkyun, Jung Hyun-Ju, Bae Kihwan, Min Byung Sun

机构信息

College of Pharmacy, Catholic University of Daegu, Gyeongsan, Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2412-6. doi: 10.1016/j.bmcl.2010.03.043. Epub 2010 Mar 11.

DOI:10.1016/j.bmcl.2010.03.043

PMID:20346658

Abstract

Three new homoisoflavonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma.

摘要

从麦冬（百合科）的根中分离出三种新的高异黄酮（1-3）。基于包括二维核磁共振在内的光谱分析确定了新代谢产物的结构。通过研究新化合物（1-3）对BEAS-2B细胞中由IL-4以及IL-4与TNF-α联合刺激产生的炎性趋化因子嗜酸性粒细胞趋化因子释放的影响，来考察其抗炎活性，该细胞模型模拟了支气管过敏性哮喘的体内情况。