伴有富含黏液的涎腺导管癌的小涎腺破骨细胞型巨细胞瘤：一例具有免疫组化分析的罕见组织学病例报告

Osteoclast-type giant cell tumor of minor salivary gland with mucin-rich salivary duct carcinoma: a case report of unusual histology with immunohistochemical analysis.

作者信息

Kusafuka Kimihide, Nakamura Satoshi, Asano Rie, Kamijo Tomoyuki, Iida Yoshiyuki, Onistuka Tetsuro, Nakajima Takashi

机构信息

Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):870-7. doi: 10.1016/j.tripleo.2009.12.021. Epub 2010 Mar 25.

DOI:10.1016/j.tripleo.2009.12.021

PMID:20346712

Abstract

OBJECTIVE

Salivary giant cell tumor (GCT) is exceedingly rare. This article presents an additional rare case of salivary GCT with salivary duct carcinoma (SDC).

STUDY DESIGN AND RESULTS

The patient was a 40-year-old Japanese male. The peripheral region of the tumor showed SDC and partly revealed a mucin accumulation with cancer nests, which was a mucin-rich variant of SDC. In the central region of the tumor, mononuclear ovoid tumor cells contained osteoclastic-type giant cells. SDC showed immunopositivity for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and Her-2, whereas the giant cell lesion was negative for GCDFP-15, AR, and Her-2. Mononuclear cells in salivary GCT showed immunopositivity for epithelial membrane antigen and p53.

CONCLUSION

The salivary GCT was thought to be neoplastic and derived from epithelial cells. The present case is the first de novo case of intraoral salivary GCT with a mucin-rich variant of SDC.

摘要

目的

涎腺巨细胞瘤（GCT）极为罕见。本文报告了1例额外的罕见涎腺GCT合并涎腺导管癌（SDC）病例。

研究设计与结果

患者为一名40岁的日本男性。肿瘤周边区域表现为SDC，部分区域可见伴有癌巢的黏液积聚，为富含黏液的SDC变异型。在肿瘤中央区域，单核卵圆形肿瘤细胞中含有破骨细胞样巨细胞。SDC对大体囊肿病液体蛋白-15（GCDFP-15）、雄激素受体（AR）和Her-2呈免疫阳性，而巨细胞病变对GCDFP-15、AR和Her-2呈阴性。涎腺GCT中的单核细胞对上皮膜抗原和p53呈免疫阳性。