局部光动力疗法治疗肛门生殖器尖锐湿疣：14 例报告及复习。

Treatment of anogenital condylomata acuminata with topical photodynamic therapy: report of 14 cases and review.

机构信息

Struttura Complessa Dipartimentale di Ginecologia ed Ostetricia, PO SS. Annunziata, Taranto, Italy.

出版信息

Int J Infect Dis. 2010 Sep;14 Suppl 3:e280-2. doi: 10.1016/j.ijid.2009.11.031. Epub 2010 Mar 25.

DOI:10.1016/j.ijid.2009.11.031

PMID:20346722

Abstract

Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging technique for the treatment of genital human papillomavirus (HPV)-induced benign and premalignant lesions. We report herein a case series of anogenital CA successfully treated with ALA-PDT and review the literature available to date on this topic. Thirteen out of 14 cases of anogenital condylomata acuminata were successfully treated with topical PDT. We conclude that PDT can be considered a highly effective and safe treatment option for anogenital condylomata acuminata. Also, considering the available literature, the best results are likely to be achieved with a 16-20% gel formulation of 5-ALA and a red light dose of 100-150J/cm(2).

摘要

光动力疗法（PDT）联合 5-氨基酮戊酸（ALA）是一种新兴的技术，可用于治疗生殖器人乳头瘤病毒（HPV）引起的良性和癌前病变。我们在此报告了一组应用 ALA-PDT 成功治疗的肛门生殖器尖锐湿疣病例，并对该主题的现有文献进行了回顾。14 例肛门生殖器尖锐湿疣中有 13 例经局部 PDT 治疗成功。我们的结论是，PDT 可被视为治疗肛门生殖器尖锐湿疣的一种高效且安全的治疗选择。此外，根据现有文献，使用 5-ALA 的 16%-20%凝胶制剂和 100-150J/cm² 的红光剂量可能会取得最佳效果。