MONICA：一款用于小鼠全身成像的紧凑型、便携式双伽马相机系统。

MONICA: a compact, portable dual gamma camera system for mouse whole-body imaging.

机构信息

Science Applications International Corporation (SAIC)-Frederick, Frederick, MD, USA.

出版信息

Nucl Med Biol. 2010 Apr;37(3):245-53. doi: 10.1016/j.nucmedbio.2009.12.003.

DOI:10.1016/j.nucmedbio.2009.12.003

PMID:20346864

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2847584/

Abstract

INTRODUCTION

We describe a compact, portable dual-gamma camera system (named "MONICA" for MObile Nuclear Imaging CAmeras) for visualizing and analyzing the whole-body biodistribution of putative diagnostic and therapeutic single photon emitting radiotracers in animals the size of mice.

METHODS

Two identical, miniature pixelated NaI(Tl) gamma cameras were fabricated and installed "looking up" through the tabletop of a compact portable cart. Mice are placed directly on the tabletop for imaging. Camera imaging performance was evaluated with phantoms and field performance was evaluated in a weeklong In-111 imaging study performed in a mouse tumor xenograft model.

RESULTS

Tc-99m performance measurements, using a photopeak energy window of 140 keV+/-10%, yielded the following results: spatial resolution (FWHM at 1 cm), 2.2 mm; sensitivity, 149 cps (counts per seconds)/MBq (5.5 cps/microCi); energy resolution (FWHM, full width at half maximum), 10.8%; count rate linearity (count rate vs. activity), r(2)=0.99 for 0-185 MBq (0-5 mCi) in the field of view (FOV); spatial uniformity, <3% count rate variation across the FOV. Tumor and whole-body distributions of the In-111 agent were well visualized in all animals in 5-min images acquired throughout the 168-h study period.

CONCLUSION

Performance measurements indicate that MONICA is well suited to whole-body single photon mouse imaging. The field study suggests that inter-device communications and user-oriented interfaces included in the MONICA design facilitate use of the system in practice. We believe that MONICA may be particularly useful early in the (cancer) drug development cycle where basic whole-body biodistribution data can direct future development of the agent under study and where logistical factors, e.g., limited imaging space, portability and, potentially, cost are important.

摘要

介绍

我们描述了一种紧凑、便携的双γ相机系统（命名为“MONICA”，代表移动核成像相机），用于可视化和分析大小如老鼠的动物体内潜在诊断和治疗单光子发射放射性示踪剂的全身生物分布。

方法

制造了两个相同的、微型像素化碘化钠（Tl）γ相机，并安装在紧凑便携推车的台面上“向上看”。将老鼠直接放在台面上进行成像。使用体模评估相机成像性能，并在小鼠肿瘤异种移植模型中进行为期一周的 In-111 成像研究中评估现场性能。

结果

使用 140keV+/-10%的光电峰能窗对 Tc-99m 性能进行测量，得到以下结果：空间分辨率（1cm 处的 FWHM），2.2mm；灵敏度，149cps（每秒计数/MBq（5.5cps/微Ci））；能量分辨率（FWHM，全宽半最大值），10.8%；计数率线性度（计数率与活度），在视场（FOV）中 0-185MBq（0-5mCi）范围内 r（2）=0.99；空间均匀性，FOV 内计数率变化<3%。在整个 168 小时研究期间，通过 5 分钟的图像，在所有动物中都很好地可视化了 In-111 制剂的肿瘤和全身分布。

结论

性能测量表明，MONICA 非常适合用于全身单光子小鼠成像。现场研究表明，MONICA 设计中包含的设备间通信和面向用户的接口，便于在实践中使用该系统。我们认为，MONICA 可能特别有用，特别是在（癌症）药物开发周期的早期，此时基本的全身生物分布数据可以指导正在研究的制剂的未来开发，并且物流因素（例如，有限的成像空间、便携性和潜在的成本）很重要。