感染澳大利亚有袋类动物的非典型 II 型样和非典型刚地弓形虫株。
Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia.
机构信息
WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia.
出版信息
Int J Parasitol. 2010 May;40(6):635-40. doi: 10.1016/j.ijpara.2010.02.008. Epub 2010 Mar 25.
Abstract
Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes.
摘要
澳大利亚地理位置孤立，拥有独特多样的野生动物物种。有袋类动物极易感染世界性寄生虫弓形虫。在通过多基因 PCR-DNA 测序（B1、SAG3、GRA6、GRA7）对 46 种有袋动物进行的 T. gondii 筛查中，有 12 种呈 PCR 阳性；大多数（67%；9/12）被非典型 II 型样或非典型菌株感染。在 B1 处检测到 6 种新等位基因，表明基因型的多样性大于先前预期。两种对有袋类动物致命的分离株对老鼠无毒。这些数据支持这样的结论，即澳大利亚的隔离可能有利于非典型祖先基因型的持续存在。
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