Institute of Neurology, WHO Collaborating Center for Research and Training in Neuroscience, Huashan Hospital, Fudan University, #12 Wulumuqi Zhong Rd., Shanghai 200040, China.
Epilepsy Res. 2010 Jun;90(1-2):16-20. doi: 10.1016/j.eplepsyres.2010.03.001. Epub 2010 Mar 26.
Studies from developed countries illustrate that adolescents with epilepsy have a higher frequency of behavioral problems than healthy or chronically ill control groups. In China, where public perception of epilepsy is relatively unfavorable, the impairment of quality of life (QOL) and its related risk factors in adolescents with epilepsy is unknown.
To identify the level of QOL and related factors among adolescents with epilepsy in China, we conducted a case-control study of 47 pairs of active adolescents with epilepsy and matched normal controls. QOL of adolescents with epilepsy was measured with the Chinese version of the "Quality of Life in Epilepsy Inventory for Adolescents 48 (QOLIE-AD-48)". Three domains unrelated to epilepsy (memory/concentration, physical functioning and social support) were used to evaluate QOL of a control group.
The mean total score of QOLIE-AD-48 of epileptic subjects was 65.6+/-14.1. Aspects of memory/concentration, physical functioning and social support of adolescent patients were generally impaired compared with those of normal controls. Age of onset, seizure worry, and fear of injury were all significantly associated with QOL.
More attention should be paid to the seizure-related psychological status of adolescents with epilepsy to improve QOL at their transitional stage of physical and mental human development.
来自发达国家的研究表明，患有癫痫的青少年比健康或慢性病对照组的行为问题发生率更高。在中国，公众对癫痫的认知相对不利，患有癫痫的青少年的生活质量（QOL）受损及其相关危险因素尚不清楚。
为了确定中国青少年癫痫患者的 QOL 水平及其相关因素，我们对 47 对活跃的青少年癫痫患者和匹配的正常对照组进行了病例对照研究。使用中文版的“青少年癫痫生活质量量表 48 项（QOLIE-AD-48）”来衡量青少年癫痫患者的 QOL。使用与癫痫无关的三个领域（记忆力/注意力、身体机能和社会支持）来评估对照组的 QOL。
癫痫患者 QOLIE-AD-48 的平均总分是 65.6±14.1。与正常对照组相比，青少年患者的记忆力/注意力、身体机能和社会支持等方面普遍受损。发病年龄、癫痫发作的担忧和对受伤的恐惧均与 QOL 显著相关。
应更加关注青少年癫痫患者与癫痫相关的心理状况，以改善他们身心发展过渡阶段的生活质量。
