心房颤动的遗传学。
Genetics of atrial fibrillation.
机构信息
Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
出版信息
Heart Fail Clin. 2010 Apr;6(2):239-47. doi: 10.1016/j.hfc.2009.12.004.
Abstract
Recent studies of atrial fibrillation (AF) have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.
摘要
最近对心房颤动 (AF) 的研究已经确定了一系列离子通道中的突变；然而，这些突变似乎是 AF 相对罕见的原因。全基因组关联研究已经确定了与 AF 相关的染色体 4 上的新变体，尽管这些变体的作用机制尚不清楚。最终，对 AF 遗传学的更深入了解应该能够深入了解这种常见心律失常的新途径、治疗靶点和诊断检测。
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