Department of Neuroradiology, Newcastle Regional Neurosciences Centre, Newcastle, UK.
Br J Radiol. 2009 Jan;82 Spec No 1:S33-8. doi: 10.1259/bjr/59367266.
Atherosclerosis presents a massive healthcare burden in both the developing and developed world. There is mounting evidence relating to the involvement of haemodynamic factors in the pathogenesis of this process. This article aims to review the current understandings that have developed in this area, and to present a demonstrative case study obtained using state of the art computational fluid dynamics (CFD) methodology to model and analyse haemodynamic factors within the atheromatous carotid artery bifurcation.
动脉粥样硬化在发达国家和发展中国家都带来了巨大的医疗负担。越来越多的证据表明血流动力学因素与这一过程的发病机制有关。本文旨在回顾这一领域的现有认识,并展示一个使用最先进的计算流体动力学 (CFD) 方法建模和分析粥样硬化颈动脉分叉处血流动力学因素的示范病例研究。