Kuhar M J
Fed Proc. 1978 Feb;37(2):153-7.
It is possible to localize opiate receptors by histochemical methods. They appear in high densities in anatomical areas associated with physiologic functions altered by opiates. They appear to mediate inhibitory responses; some of them, in certain regions could be involved in axo-axonic synapses. The immunohistochemical studies as well as the electrophysiologic results are compatible with the view that the enkephalins are the endogenous substrates for the opiate receptors.
