Δ-四氢大麻酚对工作记忆的影响：对精神分裂症有何启示？
Effects of Δ-THC on Working Memory: Implications for Schizophrenia?
作者信息
Vadhan Nehal P, Serper Mark R, Haney Margaret
机构信息
Dr. Vadhan is assistant professor of clinical psychology and Dr. Haney is associate professor of clinical neurobiology at Columbia University College of Physicians and Surgeons at the New York State Psychiatric Institute in New York City. Dr. Serper is professor of psychology at Hofstra University in Hempstead, New York.
出版信息
Prim psychiatry. 2009 Jan 1;16(4):51-99.
This article reviews the literature on the acute effects of Delta 9-tetrahydrocannabinol, the primary psychoactive component of marijuana, on working memory, and the implications for schizophrenia. Working memory deficits are a hallmark feature of schizophrenia, and have been implicated as an etiologic mechanism contributing to the onset of the disorder. Regular marijuana smokers may also exhibit subtle working memory impairment relative to healthy controls, and an association between marijuana abuse and subsequent development of schizophrenia, though controversial, has been reported in the literature. The causal role that marijuana plays in working memory impairment related to schizophrenia, however, remains unclear. Thus, this article specifically considers the acute effects of marijuana on working memory performance. The ecologic relevance and clinical significance of these findings will be examined, and directions for future research will be recommended.
本文综述了关于大麻主要精神活性成分Δ9-四氢大麻酚对工作记忆的急性影响以及对精神分裂症影响的文献。工作记忆缺陷是精神分裂症的一个标志性特征，并且被认为是导致该疾病发病的一种病因机制。与健康对照组相比，经常吸食大麻者也可能表现出轻微的工作记忆损害，而且文献中报道了大麻滥用与随后精神分裂症的发生之间的关联，尽管存在争议。然而，大麻在与精神分裂症相关的工作记忆损害中所起的因果作用仍不清楚。因此，本文特别考虑大麻对工作记忆表现的急性影响。将检验这些发现的生态学相关性和临床意义，并推荐未来研究的方向。
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