[针刺对阿尔茨海默病患者异前列腺素的影响]

[Influence of acupuncture on isoprostane in patients with Alzheimer's disease].

作者信息

Zhu Hong, Dong Ke-li, Wu Yue, Zhang Ting, Li Ruo-meng, Dai Si-si, Wang Hui-ling

机构信息

Department of TCM, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

出版信息

Zhongguo Zhen Jiu. 2010 Jan;30(1):18-21.

PMID:20353108

Abstract

OBJECTIVE

To explore the clinical therapeutic effect of acupuncture on Alzheimer's disease (AD) and its mechanism.

METHODS

Twenty patients with Alzheimer's disease were treated by acupuncture with reinforcing kidney and activating blood method for 12 weeks and Baihui (GV 20), Shenshu (BL 23), Xuehai (SP 10) and Geshu (BL 17) were selected. The clinical therapeutic effect were assessed by comparing the scores of Alzheimer's Disease Assessment Scale-Cognitive Section (ADAS-Cog) and 8-IPF2alpha concentration in cerebrospinal fluid, blood and urine before and after treatment were detected by using enzyme linked immunosorbent assay.

RESULTS

After treatment, the effective rate was 90.0%. The score of ADAS-Cog was 35. 70 +/- 14. 70 before treatment and 31. 45 +/- 4. 08 after treatment, with a significant difference (P<0. 001). The concentration of 8-IPF2alpha in cerebrospinal fluid, blood and urine were all significantly decreased after treatment (all P<0.001).

CONCLUSION

Acupuncture can improve the cognitive ability of AD patients and its possible mechanism may be relative to the decrease in lipid peroxidation in AD patients' brain.

摘要

目的

探讨针刺治疗阿尔茨海默病（AD）的临床疗效及其机制。

方法

选取20例阿尔茨海默病患者，采用补肾活血针法治疗12周，穴位选取百会（GV 20）、肾俞（BL 23）、血海（SP 10）和膈俞（BL 17）。通过比较治疗前后阿尔茨海默病评估量表认知部分（ADAS-Cog）评分评估临床疗效，采用酶联免疫吸附测定法检测治疗前后脑脊液、血液和尿液中8-异前列腺素F2α（8-IPF2α）浓度。