Department of Microbiology & Immunology, Pediatrics and Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada.
Future Microbiol. 2010 Apr;5(4):585-602. doi: 10.2217/fmb.10.22.
The history of vaccines for respiratory syncytial virus (RSV) illustrates the complex immunity and immunopathology to this ubiquitous virus, starting from the failed formalin-inactivated vaccine trials performed in the 1960s. An attractive alternative to traditional live or killed virus vaccines is a defined vaccine composed of discrete antigenic epitopes for which immunological activities have been characterized as comprehensively as possible. Here we present cumulative data on murine and human CD4, CD8 and neutralization epitopes identified in RSV proteins along with information regarding their associated immune responses and host-dependent variability. Identification and characterization of RSV epitopes is a rapidly expanding topic of research with potential contributions to the tailored design of improved safe and effective vaccines.
呼吸道合胞病毒 (RSV) 疫苗的历史说明了这种普遍存在的病毒的复杂免疫和免疫病理学，从 20 世纪 60 年代失败的福尔马林灭活疫苗试验开始。一种有吸引力的替代传统活病毒或死病毒疫苗的方法是一种由明确的抗原表位组成的定义明确的疫苗，这些表位的免疫活性已尽可能全面地进行了描述。在这里，我们提供了关于在 RSV 蛋白中鉴定的鼠和人 CD4、CD8 和中和表位的累积数据，以及有关其相关免疫反应和宿主依赖性变异性的信息。RSV 表位的鉴定和表征是一个快速发展的研究课题，有可能有助于定制设计更安全有效的疫苗。
