Institute of Microbiology, Technische Universität Braunschweig, Spielmannstr. 7, 38106 Braunschweig, Germany.
Future Microbiol. 2010 Apr;5(4):603-21. doi: 10.2217/fmb.10.16.
Pseudomonas aeruginosa is a versatile opportunistic human pathogen that is able to colonize a broad spectrum of different aquatic and soil habitats. In the environment and during pathogenesis, P. aeruginosa encounters oxygen-limited and anaerobic environments. Particularly during chronic infection of the cystic fibrosis lung, oxygen-limiting conditions seem to contribute to persistent infection. Oxygen limitation increases antibiotic tolerance, robust biofilms and alginate biosynthesis, which contribute to the persistence of this opportunistic pathogen. Despite the importance of anaerobic metabolism during persistent infection of P. aeruginosa, we are just beginning to understand the underlying regulatory network and the molecular basis of how anaerobic metabolism contributes to a persistent infection. A deeper understanding of the anaerobic physiology of P. aeruginosa will allow the identification of new antibiotic targets and new therapeutic strategies.
铜绿假单胞菌是一种多功能的机会性病原体，能够在广泛的不同水生和土壤栖息地中定植。在环境中和发病过程中，铜绿假单胞菌会遇到氧气受限和厌氧环境。特别是在囊性纤维化肺部的慢性感染中，氧气限制条件似乎有助于持续性感染。氧气限制会增加抗生素耐受性、坚固的生物膜和藻酸盐生物合成，从而导致这种机会性病原体的持续存在。尽管在铜绿假单胞菌的持续性感染中厌氧代谢非常重要，但我们才刚刚开始了解潜在的调控网络以及厌氧代谢如何有助于持续性感染的分子基础。更深入地了解铜绿假单胞菌的厌氧生理学将有助于确定新的抗生素靶点和新的治疗策略。
