Abou-Jaoude Maroun M, Nawfal Naji, Najm Robert, Shaheen Joseph, Almawi Wassim Y
Department of Surgery, Sacre-Coeur Hospital, Baabda-Hazmieh, Lebanon.
Exp Clin Transplant. 2009 Dec;7(4):214-7.
We investigated the effect of pretransplant hemoglobin level on the outcome of kidney transplant.
Patients were divided in 2 groups: group A < 10 g/dL (80 patients; PTHb < 10 g/dL), and group B > 10 g/dL (69 patients; PTHb = 10 g/dL), and were matched regarding donor age, recipient sex, blood group, donor recipient HLA, and Cytomegalovirus status.
The frequency of acute rejection, together with the timing of rejection, the need for antithymocyte globulin Fresenius rescue therapy, infection rate, and posttransplant surgical complications were comparable between both groups. While the 1-year actuarial patient and graft survival rates, delayed graft function, and slow graft function rates were comparable between both groups, longer hospital stay was required for group B (> 10 g/dL) patients (P = .005). Mean serum creatinine levels upon discharge (P = .02), at 6 months (P = .05), and 1 year (P = .02) after discharge were higher in group B (> 10 g/dL) patients. While posttransplant hemoglobin levels were lower than pretransplant levels, they were higher in group B (> 10 g/dL) compared with group A (< 10 g/dL), (P = .019).
Pretransplant hemoglobin level does not affect the outcome of kidney transplant, except for creatinine levels at 1 year.
我们研究了移植前血红蛋白水平对肾移植结果的影响。
患者分为两组：A组血红蛋白水平<10 g/dL（80例患者；移植前血红蛋白<10 g/dL），B组血红蛋白水平>10 g/dL（69例患者；移植前血红蛋白=10 g/dL），两组在供体年龄、受体性别、血型、供受体人类白细胞抗原（HLA）以及巨细胞病毒状态方面进行了匹配。
两组之间急性排斥反应的频率、排斥反应发生的时间、抗胸腺细胞球蛋白（Fresenius）挽救治疗的需求、感染率以及移植后手术并发症相当。虽然两组之间1年实际患者和移植物存活率、移植肾功能延迟恢复以及移植肾功能缓慢恢复率相当，但B组（血红蛋白>10 g/dL）患者需要更长的住院时间（P = 0.005）。出院时（P = 0.02）、出院后6个月（P = 0.05）以及1年（P = 0.02）时，B组（血红蛋白>10 g/dL）患者的平均血清肌酐水平更高。虽然移植后血红蛋白水平低于移植前水平，但与A组（血红蛋白<10 g/dL）相比，B组（血红蛋白>10 g/dL）的水平更高（P = 0.019）。
移植前血红蛋白水平除了对1年时的肌酐水平有影响外，不影响肾移植结果。
