反式白藜芦醇的抗抑郁样作用：涉及 5-羟色胺和去甲肾上腺素系统。
Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system.
机构信息
J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, University of Florida, Gainesville, FL 32611, USA.
出版信息
Eur Neuropsychopharmacol. 2010 Jun;20(6):405-13. doi: 10.1016/j.euroneuro.2010.02.013. Epub 2010 Mar 30.
The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation.
通过行为学和神经化学方法评价了白藜芦醇（一种存在于虎杖中的酚类化合物）的抗抑郁样作用。白藜芦醇（灌胃 20、40 和 80mg/kg）显著降低了绝望试验中小鼠模型的不动时间，但不影响运动活性。两种行为模型和神经化学测定表明，白藜芦醇在 40 或 80mg/kg 剂量下可显著增加脑区的 5-羟色胺和去甲肾上腺素水平。此外，白藜芦醇剂量依赖性地抑制 MAO-A 活性。这些发现表明，白藜芦醇的抗抑郁样作用可能与 5-羟色胺能和去甲肾上腺素能的激活有关。
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