School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Pharmacol Biochem Behav. 2013 Sep;110:224-30. doi: 10.1016/j.pbb.2013.07.007. Epub 2013 Jul 16.
In the present study, the antidepressant-like effect of bacopaside I, a saponin compound present in the Bacopa monniera plant, was evaluated by behavioral and neurochemical methods. Bacopaside I (50, 15 and 5 mg/kg) was given to mice via oral gavage for 7 successive days. The treatment significantly decreased the immobility time in mouse models of despair tests, but it did not influence locomotor activity. Neurochemical assays suggested that treatment by bacopaside I (50, 15 and 5 mg/kg) improved brain antioxidant activity to varying degrees after the behavioral despair test. Bacopaside I (15 and 5 mg/kg) significantly reversed reserpine-induced depressive-like behaviors, including low temperature and ptosis. Conversely, bacopaside I did not affect either brain MAO-A or MAO-B activity after the behavioral despair test in mice. Additionally, 5-hydroxytryptophan (a precursor of 5-serotonin) was not involved in the antidepressant-like effect of bacopaside I. These findings indicated that the antidepressant-like effect of bacopaside I might be related to both antioxidant activation and noradrenergic activation, although the exact mechanism remains to be further elucidated.
在本研究中，通过行为学和神经化学方法评估了存在于假马齿苋中的皂苷化合物 Bacopaside I 的抗抑郁样作用。Bacopaside I（50、15 和 5mg/kg）通过口服灌胃连续 7 天给予小鼠。该治疗显著减少了绝望试验中小鼠模型的不动时间，但不影响运动活性。神经化学分析表明，Bacopaside I（50、15 和 5mg/kg）处理在行为绝望试验后不同程度地改善了大脑的抗氧化活性。Bacopaside I（15 和 5mg/kg）显著逆转了利血平诱导的抑郁样行为，包括低温和眼睑下垂。相反，Bacopaside I 处理后，在行为绝望试验中不影响大脑 MAO-A 或 MAO-B 活性。此外，5-羟色氨酸（5-血清素的前体）不参与 Bacopaside I 的抗抑郁样作用。这些发现表明，Bacopaside I 的抗抑郁样作用可能与抗氧化剂激活和去甲肾上腺素能激活都有关，尽管确切的机制仍有待进一步阐明。
