Berdajs Denis, Bürki Marco, Michelis Alexandre, von Segesser Ludwig K
Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, CHUV, University Hospital Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland.
Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):910-3. doi: 10.1510/icvts.2010.235127. Epub 2010 Mar 30.
Fibrin glue products and collagen patches are frequently used as a sealing product, preventing surgical side bleedings. This is especially true in the field of cardiovascular surgery, where increasing numbers of patients are being operated with antiplatelet and anticoagulation therapy. The aim of this report was, in an in vitro hemodynamic setting, to examine the sealant properties of the TachoSil (Nycomed Pharma, Linz, Austria) patch. Burst pressure and normal force of 15 TachoSil sealed defects were measured. This was determined in a closed hydraulic system. Mean burst pressure load for a 5-mm defect was 69+/-11.4 mmHg; for a 7-mm defect was 63+/-16 mmHg; and, 62+/-16 mmHg for the defect with a diameter of 10 mm (P>0.05). The mean calculated normal force was as follows: 0.91+/-0.15 N for the 5 mm defect, 6.5+/-1.6 N for the 7 mm, and 8.1+/-0.75 N for the 10 mm defect. The TachoSil patch has the capability to seal small defects. However, at the larger defects the seal character was significantly reduced. These results suggest that the device may be a good alternative for hemostasis for small defects. The capacity to curtail or stop hemorrhage at the larger defects is unlikely.
纤维蛋白胶产品和胶原蛋白贴片经常被用作密封产品，以防止手术部位出血。在心血管外科领域尤其如此，在该领域越来越多的患者在接受抗血小板和抗凝治疗的情况下接受手术。本报告的目的是在体外血流动力学环境中，研究速即纱（奥地利林茨Nycomed制药公司）贴片的密封性能。测量了15个速即纱密封缺损的破裂压力和法向力。这是在一个封闭的液压系统中测定的。5毫米缺损的平均破裂压力负荷为69±11.4毫米汞柱；7毫米缺损为63±16毫米汞柱；直径10毫米的缺损为62±16毫米汞柱（P>0.05）。计算出的平均法向力如下：5毫米缺损为0.91±0.15牛，7毫米缺损为6.5±1.6牛，10毫米缺损为8.1±0.75牛。速即纱贴片有能力密封小缺损。然而，对于较大的缺损，密封性能明显降低。这些结果表明，该装置可能是小缺损止血的一个良好替代方案。对于较大缺损，减少或止血的能力不太可能实现。
