Micari A, Vadalà G, Biamino G
GVM Care and Research, Palermo, Italy.
J Cardiovasc Surg (Torino). 2010 Apr;51(2):233-43.
In the last two decades the endovascular treatment of peripheral arterial occlusive disease (PAOD) has gained a widespread and predominant role. New technologies have developed in the last years as atherectomy devices, self expandible nitinol stents, drug eluting devices (stent and balloons), absorbable stents. In recent years, growing interest has been dedicated to laser technology due to device improvements and literature data reporting safety and efficacy of excimer laser. The role of this new endovascular technique for the treatment of atherosclerotic arterial diseases should be considered with regard to two fields of interest: the claudicatio intermittens (CI) and the critical limb ischemia (CLI). A 20-year history with medical lasers has proven that not all lasers are equal. Lasers used and studied in the late 1980s and 1990s had poor outcomes due to inappropriate laser selection and undefined laser techniques. Over the last 10 years, multicenter studies with the excimer laser confirm that case selection, appropriate utilization of equipment, application of safe lasing techniques, and knowledge of indications and contraindications, all contribute to the successful application of laser-assisted angioplasty in complex coronary and peripheral artery disease. If applied properly, the Excimer Laser is a useful technique to transform complex obstructive arterial disease into more treatable lesions, improving the results of endovascular treatment and lowering the threshold of intervention for ''untreatable'' patients. New larger studies are requested to assess the definitive role of this technique in PAD treatment and limb salvage. This review will discuss the Laser Phisics and application in PAD along with the clinical data available to support the Excimer Laser as a reliable technology for endovascular intervention.
在过去二十年中,外周动脉闭塞性疾病(PAOD)的血管内治疗已获得广泛且主导性的地位。近年来,诸如旋切装置、自膨胀镍钛诺支架、药物洗脱装置(支架和球囊)、可吸收支架等新技术不断涌现。近年来,由于设备的改进以及有关准分子激光安全性和有效性的文献数据报道,人们对激光技术的兴趣与日俱增。对于这种用于治疗动脉粥样硬化性疾病的新型血管内技术的作用,应从两个关注领域来考虑:间歇性跛行(CI)和严重肢体缺血(CLI)。20年的医用激光应用历史证明,并非所有激光都是一样的。20世纪80年代末和90年代使用和研究的激光,由于激光选择不当和激光技术不明确,效果不佳。在过去10年中,有关准分子激光的多中心研究证实,病例选择、设备的合理使用、安全激光技术的应用以及对适应症和禁忌症的了解,都有助于激光辅助血管成形术在复杂冠状动脉和外周动脉疾病中的成功应用。如果应用得当,准分子激光是一种有用的技术,可将复杂的阻塞性动脉疾病转化为更易治疗的病变,改善血管内治疗效果,并降低对“不可治疗”患者的干预门槛。需要开展新的更大规模研究,以评估该技术在PAD治疗和肢体挽救中的决定性作用。本综述将讨论激光物理学及其在PAD中的应用,以及支持准分子激光作为血管内介入可靠技术的现有临床数据。