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放射治疗：脑转移瘤治疗中的神经认知考虑。

Radiotherapy: Neurocognitive considerations in the treatment of brain metastases.

机构信息

Department of Neurosurgery, The Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, ND-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

出版信息

Nat Rev Clin Oncol. 2010 Apr;7(4):185-6. doi: 10.1038/nrclinonc.2010.30.

DOI:10.1038/nrclinonc.2010.30
PMID:20354539
Abstract

The results of a randomized, controlled trial investigating the neurocognitive effects of stereotactic radiosurgery (SRS), with or without whole-brain radiation therapy (WBRT), to treat brain metastases demonstrated a significant reduction in learning and memory, associated with the addition of WBRT to SRS. the results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases.

摘要

一项随机对照试验研究了立体定向放射外科（SRS）联合或不联合全脑放疗（WBRT）治疗脑转移瘤的神经认知效应，结果显示，与 SRS 联合 WBRT 相比，WBRT 的加入显著降低了学习和记忆能力。这些结果表明，SRS 单药治疗是脑转移瘤的一种有效且安全的初始治疗策略。

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本文引用的文献

1
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Lancet Oncol. 2009 Nov;10(11):1037-44. doi: 10.1016/S1470-2045(09)70263-3. Epub 2009 Oct 2.
2
Adjuvant whole brain radiotherapy: strong emotions decide but rational studies are needed.辅助性全脑放疗：强烈的情感主导决策，但仍需要理性研究。
Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1305-9. doi: 10.1016/j.ijrobp.2007.11.047. Epub 2008 Jan 30.
3
Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone.
非小细胞肺癌脑转移患者的新生存评分。
Strahlenther Onkol. 2013 Sep;189(9):777-81. doi: 10.1007/s00066-013-0362-x. Epub 2013 Jun 7.
4
Using lithium as a neuroprotective agent in patients with cancer.在癌症患者中使用锂作为神经保护剂。
BMC Med. 2012 Nov 2;10:131. doi: 10.1186/1741-7015-10-131.
5
Prophylactic cranial irradiation: the state of the art and areas of uncertainty.预防性颅脑照射：现状与不确定领域
Clin Transl Oncol. 2012 Apr;14(4):317-9. doi: 10.1007/s12094-012-0801-7.
6
Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation.自愿跑步可预防全脑照射后进行性记忆下降，并增加成年海马神经发生和生长因子表达。
Cancer Res. 2010 Nov 15;70(22):9329-38. doi: 10.1158/0008-5472.CAN-10-1854. Epub 2010 Sep 30.
接受全脑放疗加立体定向放射外科治疗或仅接受立体定向放射外科治疗的脑转移患者的神经认知功能。
Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1388-95. doi: 10.1016/j.ijrobp.2007.03.048.
4
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N Engl J Med. 1990 Feb 22;322(8):494-500. doi: 10.1056/NEJM199002223220802.