Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy.
Nat Rev Clin Oncol. 2010 Apr;7(4):190-1. doi: 10.1038/nrclinonc.2010.32.
Patients who undergo hepatic surgery for initially resectable liver metastases from colorectal cancer have a 70% risk of relapse. a recent phase III randomized trial has failed to demonstrate an improvement in disease-free survival with the addition of irinotecan to 5-fluorouracil and folinic acid as adjuvant treatment for patients with radically resected colorectal cancer with liver metastases.
对于最初可切除的结直肠癌肝转移患者进行肝切除术，有 70%的复发风险。最近一项 III 期随机试验未能证明在根治性切除伴肝转移的结直肠癌患者的辅助治疗中添加伊立替康到 5-氟尿嘧啶和亚叶酸中可以改善无病生存期。
