Honneth J, Nehen H G, Haseke J
Contilia GmbH, Geriatrie-Zentrum Haus Berge, Elisabeth-Krankenhaus Essen GmbH, Essen, Deutschland.
Z Gerontol Geriatr. 2010 Jun;43(3):177-9. doi: 10.1007/s00391-010-0101-1. Epub 2010 Apr 1.
Alzheimer's disease (AD) is the most frequent form of dementia worldwide. The increasing incidence of AD is due to the dramatic rise in life expectancy. Generally, AD shows a multifactorial etiology and manifests itself only at an older age. However, a small percentage of cases have a monogenic cause, are inherited as an autosomal dominant trait, and begin much earlier. In these cases, molecular analysis and genetic consultation may make sense.
阿尔茨海默病(AD)是全球最常见的痴呆形式。AD发病率的上升归因于预期寿命的显著提高。一般来说,AD呈现多因素病因,且仅在老年时表现出来。然而,一小部分病例有单基因病因,以常染色体显性特征遗传,且发病要早得多。在这些病例中,分子分析和遗传咨询可能是有意义的。