Ozturk Ayla, Desai Purnima P, Minster Ryan L, Dekosky Steven T, Kamboh M Ilyas
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
Neurobiol Aging. 2005 Aug-Sep;26(8):1161-5. doi: 10.1016/j.neurobiolaging.2004.11.001. Epub 2004 Dec 18.
Linkage studies suggest the presence of putative risk and/or age-at-onset genes for Alzheimer's disease on Chromosome 10. Recently, a genomic converging approach using a combination of linkage, expression and association studies has reported significant associations of the glutathione S-transferase omega 1 and 2 (GSTO1 and GSTO2) genes and possibly the protease serine 11 (PRSS11) gene on chromosome 10 with age-at-onset, but not risk, for Alzheimer's disease (AD) and Parkinson disease. We investigated the association of the reported three polymorphisms in 990 sporadic late-onset AD cases (26% autopsy confirmed) and 735 controls. In our sample, we found no association either with age-at-onset in AD cases or with disease risk in the case-control cohort. However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD.
连锁研究表明，10号染色体上存在阿尔茨海默病的假定风险基因和/或发病年龄基因。最近，一种结合连锁、表达和关联研究的基因组收敛方法报告称，10号染色体上的谷胱甘肽S-转移酶ω1和2（GSTO1和GSTO2）基因以及可能的丝氨酸蛋白酶11（PRSS11）基因与阿尔茨海默病（AD）和帕金森病的发病年龄显著相关，但与风险无关。我们调查了990例散发性晚发性AD病例（26%经尸检证实）和735名对照中报告的三种多态性的关联。在我们的样本中，我们未发现与AD病例的发病年龄或病例对照队列中的疾病风险存在关联。然而，单倍型分析显示一种单倍型与AD风险存在适度关联（p = 0.04）。需要筛选这些基因中的其他标记，以探索它们在AD病因学中的作用。
