聚合物囊泡的共价附着到表面。

Covalent attachment of polymersomes to surfaces.

机构信息

Institute of Physical Chemistry, University of Hamburg, Grindelallee 117, D-20146 Hamburg, Germany.

出版信息

Langmuir. 2010 May 18;26(10):6927-31. doi: 10.1021/la904175u.

PMID:20355708

Abstract

We show that vesicles made of block copolymers with aldehyde end groups can be covalently attached to aminated and non-aminated, untreated glass surfaces. The attached vesicles were sufficiently stable to allow a detailed investigation of vesicle shapes by confocal laser scanning microscopy (CLSM) and AFM in aqueous solutions allowing reconstruction of 3D images of the vesicle structure. Covalently attached PCL-PEO, PLA-PEO, and PI-PEO block copolymer vesicles have different footprint areas and different shapes due to their differences in bilayer stiffness.

摘要

我们证明，具有醛端基的嵌段共聚物制成的囊泡可以共价附着到氨基化和非氨基化、未经处理的玻璃表面上。附着的囊泡足够稳定，可以允许在水溶液中通过共聚焦激光扫描显微镜 (CLSM) 和原子力显微镜 (AFM) 进行囊泡形状的详细研究，从而可以重建囊泡结构的 3D 图像。由于双层硬度的差异，共价附着的 PCL-PEO、PLA-PEO 和 PI-PEO 嵌段共聚物囊泡具有不同的足迹面积和不同的形状。