Fried G, Samuelson U
Department of Physiology, Karolinska Institute, Stockholm, Sweden.
Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1330-6. doi: 10.1016/0002-9378(91)90709-z.
The control of uterine blood flow is regulated by a number of factors including vasoactive present in the endothelium and the perivascular nerves. We examined the effects of two vasoactive peptides, endothelin and neuropeptide Y, on segments of human uterine arteries and veins in vitro. We found endothelin, a potent vasoconstrictor in the uterine artery and vein, giving a slow and long-lasting contraction starting at 10(-9) mol/L. At this concentration, the established vasoconstrictor noradrenaline had almost no effect. Neuropeptide Y had no effect of its own in the human uterine artery, but increased basal tone in uterine veins, and at higher concentrations triggered spontaneous contractions. Neuropeptide Y (10(-7) mol/L) often, but not always, enhanced the contraction induced by noradrenaline (10(-6) mol/L). Neuropeptide Y (10(-7) mol/L) also enhanced the contraction induced by transmural nerve stimulation (20 Hz, 0.4 msec). We conclude that endothelin and neuropeptide Y may modulate the control of human uterine circulation.
子宫血流的控制受多种因素调节，包括内皮和血管周围神经中存在的血管活性物质。我们在体外研究了两种血管活性肽，内皮素和神经肽Y，对人子宫动脉和静脉节段的影响。我们发现，内皮素是子宫动脉和静脉中的一种强效血管收缩剂，在10^(-9)mol/L时开始产生缓慢而持久的收缩。在此浓度下，已确定的血管收缩剂去甲肾上腺素几乎没有作用。神经肽Y对人子宫动脉本身没有作用，但会增加子宫静脉的基础张力，在较高浓度时会引发自发收缩。神经肽Y（10^(-7)mol/L）通常但并非总是增强去甲肾上腺素（10^(-6)mol/L）诱导的收缩。神经肽Y（10^(-7)mol/L）也增强了经壁神经刺激（20Hz，0.4毫秒）诱导的收缩。我们得出结论，内皮素和神经肽Y可能调节人子宫循环的控制。
