Kim Kyungsun, Kim Ikyon
Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
J Comb Chem. 2010 May 10;12(3):379-82. doi: 10.1021/cc100015k.
Rapid generation of a small library of highly functionalized indolizonones was realized by exploiting three palladium-catalyzed cross-coupling reactions of 2-iodoindolizinones which in turn were readily accessed via sequential iodine-mediated cyclization/1,2-shift reactions of propargylic alcohols.
通过利用2-碘中氮茚酮的三种钯催化交叉偶联反应，快速生成了一个小的高官能化中氮茚酮文库，而2-碘中氮茚酮又可通过炔丙醇的顺序碘介导环化/1,2-迁移反应轻松获得。
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