通过钯催化的多米诺序列快速合成高取代的吲哚嗪酮。
Expeditious synthesis of highly substituted indolizinones via a palladium-catalyzed domino sequence.
机构信息
Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
出版信息
Org Lett. 2010 Jun 4;12(11):2500-3. doi: 10.1021/ol1006778.
PMID:20443571
Abstract
A direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols using a palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift is described.
摘要
本文描述了一种钯催化的级联反应，包括氨钯化、还原消除和 1,2-迁移，从叔丙炔醇直接一锅法制备多取代吲哚嗪酮。
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