Guan Jin-Qun, Wang Lu-Ning, Zhang Xi, Jiang Tian-Zi, An Ning-Yu, Wang Qi-Feng, Zhang Jun
Department of Nanlou Neurology, Chinese PLA General Hospital, Beijing 100853, China. Email:
Zhonghua Nei Ke Za Zhi. 2010 Feb;49(2):107-10.
To measure the microstructural differences in the brains of participants with amnestic mild cognitive impairment (aMCI) and compare with a control group using a magnetic resonance diffusion tensor imaging (DTI) technique with fully automated image analysis tools.
A standardized clinical and neuropsychological evaluation was conducted on each subject. 31 participants (15 participants with aMCI, 16 healthy elderly adults) underwent magnetic resonance imaging (MRI)-based DTI. To control the effects of anatomical variation, the diffusion images of all participants were registered to standard anatomical space. Voxel-by-voxel comparisons showed significant regional reductions in white matter regions of fractional anisotropy (FA) in the participants with aMCI as compared with the controls.
Significantly decreased FA value measurements (P < 0.001) were observed in the right frontal white matter in participants with aMCI. Moreover, there was a statistically significant difference between the patients with aMCI and controls in considering the small regions of bilateral superior frontal gyrus white matter (P < 0.001).
White matter damage of frontal lobe may play an important role in histopathologic changes associated with amnestic mild cognitive impairment.
使用磁共振扩散张量成像（DTI）技术及全自动图像分析工具，测量遗忘型轻度认知障碍（aMCI）参与者大脑的微观结构差异，并与对照组进行比较。
对每位受试者进行标准化临床和神经心理学评估。31名参与者（15名aMCI参与者，16名健康老年人）接受了基于磁共振成像（MRI）的DTI检查。为控制解剖变异的影响，将所有参与者的扩散图像配准到标准解剖空间。逐体素比较显示，与对照组相比，aMCI参与者白质区域的分数各向异性（FA）显著降低。
在aMCI参与者的右侧额叶白质中观察到FA值测量显著降低（P < 0.001）。此外，在考虑双侧额上回白质的小区域时，aMCI患者与对照组之间存在统计学显著差异（P < 0.001）。
额叶白质损伤可能在与遗忘型轻度认知障碍相关的组织病理学变化中起重要作用。
