初诊2型糖尿病患者脂肪细胞脂肪酸结合蛋白与脂联素比值与股动脉内膜中层厚度及内皮依赖性血管舒张功能的关系

[Relationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitus].

作者信息

Xiao Yang, Yao Lan, Li Xing, Zhong Hui, Chen Xiao-Yan, Tang Wei-Li, Liu Shi-Ping, Xu Ai-Min, Zhou Zhi-Guang

机构信息

Department of Endocrinology, Second Xiangya Hospital, Diabetes Center, Institute of Metabolism & Endocrinology, Central South University, Changsha 410011, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2010 Jan 26;90(4):231-5.

PMID:20356535

Abstract

OBJECTIVE

To explore the relationship between plasma adipocyte fatty acid-binding protein (A-FABP), adiponectin (APN) levels and A-FABP/APN ratio with femoral intima-media thickness (FA-IMT) and endothelium-dependent vasodilation in patients with newly diagnosed type 2 diabetes mellitus (T2DM).

METHODS

Plasma A-FABP and APN in 133 patients with newly diagnosed T2DM were measured by enzyme-linked immunosorbent assays. FA-IMT, endothelium-dependent and independent vasodilation of brachial artery was measured by high-resolution vascular ultrasound. Upper quartile of FA-IMT was regarded as a criterion of elevated FA-IMT, defined as early atherosclerosis (AS). The patients were subdivided into low FA-IMT group (FA-IMT < 0.60 mm, n = 34), middle FA-IMT group (0.60 mm </= FA-IMT < 0.73 mm, n = 33), high FA-IMT group (0.73 mm </= FA-IMT < 0.80 mm, n = 33) and early AS group (FA-IMT >/= 0.80 mm, n = 33).

RESULTS

Plasma A-FABP/APN ratio was higher in early AS group than in low IMT control group [A-FABP/APN x 1000, 3.9(2.8 approximately 6.1) vs 2.9(1.8 approximately 5.7), P < 0.05]. FA-IMT correlated positively with plasma A-FABP/APN ratio (r = 0.216, P = 0.006) and negatively with APN (r = -0.179, P = 0.020). After adjusted for age, gender and BMI, FA-IMT still correlated positively with plasma A-FABP/APN ratio (r = 0.217, P = 0.007) and negatively with APN (r = -0.172, P = 0.026). Endothelium-dependent vasodilation correlated negatively with plasma A-FABP/APN ratio (r = -0.166, P = 0.028). After adjusted for age, gender and BMI, endothelium-dependent vasodilation still correlated negatively with plasma A-FABP/APN ratio (r = -0.153, P = 0.042).

CONCLUSION

Plasma A-FABP/APN ratio is closely associated with FA-IMT and endothelium-dependent vasodilation. Plasma A-FABP/APN ratio may be a better clinical marker of AS and endothelial dysfunction than A-FABP or APN alone in patients with newly diagnosed T2DM.

摘要

目的

探讨新诊断2型糖尿病（T2DM）患者血浆脂肪细胞脂肪酸结合蛋白（A-FABP）、脂联素（APN）水平及A-FABP/APN比值与股动脉内膜中层厚度（FA-IMT）和内皮依赖性血管舒张功能的关系。

方法

采用酶联免疫吸附测定法检测133例新诊断T2DM患者的血浆A-FABP和APN水平。采用高分辨率血管超声测量肱动脉的FA-IMT、内皮依赖性和非内皮依赖性血管舒张功能。将FA-IMT的上四分位数作为FA-IMT升高的标准，定义为早期动脉粥样硬化（AS）。将患者分为低FA-IMT组（FA-IMT<0.60mm，n=34）、中FA-IMT组（0.60mm≤FA-IMT<0.73mm，n=33）、高FA-IMT组（0.73mm≤FA-IMT<0.80mm，n=33）和早期AS组（FA-IMT≥0.80mm，n=33）。

结果

早期AS组血浆A-FABP/APN比值高于低IMT对照组[A-FABP/APN×1000，3.9（2.8～6.1）对2.9（1.8～5.7），P<0.05]。FA-IMT与血浆A-FABP/APN比值呈正相关（r=0.216，P=0.006），与APN呈负相关（r=-0.179，P=0.020）。校正年龄、性别和BMI后，FA-IMT仍与血浆A-FABP/APN比值呈正相关（r=0.217，P=0.007），与APN呈负相关（r=-0.172，P=0.026）。内皮依赖性血管舒张功能与血浆A-FABP/APN比值呈负相关（r=-0.166，P=0.028）。校正年龄、性别和BMI后，内皮依赖性血管舒张功能仍与血浆A-FABP/APN比值呈负相关（r=-0.153，P=0.042）。