Xiao Yang, Yao Lan, Li Xing, Zhong Hui, Chen Xiao-Yan, Tang Wei-Li, Liu Shi-Ping, Xu Ai-Min, Zhou Zhi-Guang
Department of Endocrinology, Second Xiangya Hospital, Diabetes Center, Institute of Metabolism & Endocrinology, Central South University, Changsha 410011, China.
Zhonghua Yi Xue Za Zhi. 2010 Jan 26;90(4):231-5.
To explore the relationship between plasma adipocyte fatty acid-binding protein (A-FABP), adiponectin (APN) levels and A-FABP/APN ratio with femoral intima-media thickness (FA-IMT) and endothelium-dependent vasodilation in patients with newly diagnosed type 2 diabetes mellitus (T2DM).
Plasma A-FABP and APN in 133 patients with newly diagnosed T2DM were measured by enzyme-linked immunosorbent assays. FA-IMT, endothelium-dependent and independent vasodilation of brachial artery was measured by high-resolution vascular ultrasound. Upper quartile of FA-IMT was regarded as a criterion of elevated FA-IMT, defined as early atherosclerosis (AS). The patients were subdivided into low FA-IMT group (FA-IMT < 0.60 mm, n = 34), middle FA-IMT group (0.60 mm </= FA-IMT < 0.73 mm, n = 33), high FA-IMT group (0.73 mm </= FA-IMT < 0.80 mm, n = 33) and early AS group (FA-IMT >/= 0.80 mm, n = 33).
Plasma A-FABP/APN ratio was higher in early AS group than in low IMT control group [A-FABP/APN x 1000, 3.9(2.8 approximately 6.1) vs 2.9(1.8 approximately 5.7), P < 0.05]. FA-IMT correlated positively with plasma A-FABP/APN ratio (r = 0.216, P = 0.006) and negatively with APN (r = -0.179, P = 0.020). After adjusted for age, gender and BMI, FA-IMT still correlated positively with plasma A-FABP/APN ratio (r = 0.217, P = 0.007) and negatively with APN (r = -0.172, P = 0.026). Endothelium-dependent vasodilation correlated negatively with plasma A-FABP/APN ratio (r = -0.166, P = 0.028). After adjusted for age, gender and BMI, endothelium-dependent vasodilation still correlated negatively with plasma A-FABP/APN ratio (r = -0.153, P = 0.042).
Plasma A-FABP/APN ratio is closely associated with FA-IMT and endothelium-dependent vasodilation. Plasma A-FABP/APN ratio may be a better clinical marker of AS and endothelial dysfunction than A-FABP or APN alone in patients with newly diagnosed T2DM.
探讨新诊断2型糖尿病（T2DM）患者血浆脂肪细胞脂肪酸结合蛋白（A-FABP）、脂联素（APN）水平及A-FABP/APN比值与股动脉内膜中层厚度（FA-IMT）和内皮依赖性血管舒张功能的关系。
采用酶联免疫吸附测定法检测133例新诊断T2DM患者的血浆A-FABP和APN水平。采用高分辨率血管超声测量肱动脉的FA-IMT、内皮依赖性和非内皮依赖性血管舒张功能。将FA-IMT的上四分位数作为FA-IMT升高的标准，定义为早期动脉粥样硬化（AS）。将患者分为低FA-IMT组（FA-IMT<0.60mm，n=34）、中FA-IMT组（0.60mm≤FA-IMT<0.73mm，n=33）、高FA-IMT组（0.73mm≤FA-IMT<0.80mm，n=33）和早期AS组（FA-IMT≥0.80mm，n=33）。
早期AS组血浆A-FABP/APN比值高于低IMT对照组[A-FABP/APN×1000，3.9（2.8～6.1）对2.9（1.8～5.7），P<0.05]。FA-IMT与血浆A-FABP/APN比值呈正相关（r=0.216，P=0.006），与APN呈负相关（r=-0.179，P=0.020）。校正年龄、性别和BMI后，FA-IMT仍与血浆A-FABP/APN比值呈正相关（r=0.217，P=0.007），与APN呈负相关（r=-0.172，P=0.026）。内皮依赖性血管舒张功能与血浆A-FABP/APN比值呈负相关（r=-0.166，P=0.028）。校正年龄、性别和BMI后，内皮依赖性血管舒张功能仍与血浆A-FABP/APN比值呈负相关（r=-0.153，P=0.042）。
血浆A-FABP/APN比值与FA-IMT和内皮依赖性血管舒张功能密切相关。在新诊断的T2DM患者中，血浆A-FABP/APN比值可能比单独的A-FABP或APN是更好的AS和内皮功能障碍的临床标志物。
