Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 WenHuaXi Road, Jinan 250012, China.
J Clin Neurosci. 2010 Jun;17(6):679-84. doi: 10.1016/j.jocn.2009.11.001. Epub 2010 Mar 30.
The organic anion-transporting polypeptides (rodents: Oatps; human: OATPs) belong to the growing family of organic anion/prostaglandin transporters and are important components of the active efflux transport system at the choroid plexus epithelial cells. OATPs facilitate the elimination of xenobiotics and endogenous waste from the cerebrospinal fluid and prevent waste accumulation in the central nervous system (CNS). This review summarizes the structures, regulations and roles of Oatps/OATPs at the choroid plexus in drug delivery to the CNS.
有机阴离子转运多肽（啮齿动物：Oatps；人类：OATPs）属于不断发展的有机阴离子/前列腺素转运体家族，是脉络丛上皮细胞中主动外排转运系统的重要组成部分。OATPs 有助于将外源性物质和内源性废物从脑脊液中排出，防止废物在中枢神经系统（CNS）中积累。本综述总结了 Oatps/OATPs 在脉络丛中的结构、调节和作用，以及它们在药物向 CNS 递送中的作用。
