Vasques Xavier, Cif Laura, Mennessier Gérard, Coubes Philippe
Service de Neurochirurgie, CHRU Montpellier, Montpellier, France.
Stereotact Funct Neurosurg. 2010;88(3):129-37. doi: 10.1159/000303524. Epub 2010 Apr 1.
In nearly all deep brain stimulation (DBS) applications, the same quadripolar electrode design is used for different anatomical targets even if shape and volume differences exist between nuclei. Taking into account the electrode location within the internal globus pallidus (GPi) and the size of the GPi, 2 electrodes were designed in order to improve the therapeutic benefit, to minimize side effects from DBS and to obtain a more homogeneous electric field distribution. The electrodes were evaluated numerically by using a stereotactic model measuring the correlation between the electric field and the GPi. The model was applied to 26 dystonodyskinetic patients who underwent surgery for a bilateral lead implantation into the posteroventral part of the GPi. The designed electrodes produced a more homogeneous distribution of the electric field than the quadripolar electrode.
在几乎所有的深部脑刺激（DBS）应用中，即使不同核团之间存在形状和体积差异，相同的四极电极设计也用于不同的解剖靶点。考虑到电极在苍白球内侧部（GPi）内的位置以及GPi的大小，设计了2种电极，以提高治疗效果，将DBS的副作用降至最低，并获得更均匀的电场分布。通过使用立体定向模型测量电场与GPi之间的相关性，对电极进行了数值评估。该模型应用于26例患有肌张力障碍性运动障碍的患者，这些患者接受了双侧电极植入GPi后腹侧部的手术。与四极电极相比，设计的电极产生了更均匀的电场分布。
