Martini M Zillo, Lemos C A, Shinohara E Hitoshi
Stomatology Department, Dental School, University of Sao Paulo, Sao Paulo, Brasil.
Minerva Stomatol. 2010 Mar;59(3):139-42.
Angina bullosa hemorrhagica is characterized by the sudden appearance of solitary or multiple hemorrhagic blisters on oral mucosa, with diameters ranging from 2 mm to 3 cm. The soft palate is most commonly affected, but angina bullosa hemorrhagica may also appear on the buccal mucosa, lips and tongue border. Clinically, the blisters have a dark red to purple appearance, and may or may not be painful. The blisters usually break, releasing bloody content and leaving an ulcer surface that heals within 7 to 10 days. In this article the authors describe four cases of angina bullosa hemorrhagica attended in Stomatology Department of Dental School, Sao Paulo State University. In case 1, a 29-year-old male presented with a sudden hemorrhagic blister on the soft palate. A drainage was performed and after seven days of follow-up the patient reported no symptoms. In case 2, a 63-year-old male presented complaining of a blister on the palate six days earlier that had spontaneously broken. General exam showed hypertension under medical control. An incisional biopsy was performed and after seven days follow-up the healing was completed. In case 3, a 61-year-old male arrived complaining of a sudden appearance of an hemorrhagic blister on the soft palate that had spontaneously broken. The patient had systemic hypertension under medical control. The ulcer healed in 10 days follow-up. In case 4, a 49-year-old woman presented complaining of pain and an ulcer on the soft palate. The patient reported the rapid onset of a blood blister during a meal that broke in few minutes. The resolution occurred after 14 days. Angina bullosa hemorrhagica seems to be more common than reported in the literature and knowledge of the condition is important to right diagnosis and approach when necessary.
出血性大疱性口炎的特征是口腔黏膜上突然出现单个或多个出血性水疱，直径从2毫米到3厘米不等。软腭最常受累，但出血性大疱性口炎也可能出现在颊黏膜、嘴唇和舌缘。临床上，水疱呈暗红色至紫色，可能疼痛也可能不痛。水疱通常会破裂，流出血性内容物，留下溃疡面，在7至10天内愈合。在本文中，作者描述了圣保罗州立大学牙科学院口腔医学部收治的4例出血性大疱性口炎病例。病例1，一名29岁男性，软腭突然出现一个出血性水疱。进行了引流，随访7天后患者报告无任何症状。病例2，一名63岁男性，主诉6天前腭部出现一个水疱，已自行破裂。全身检查显示高血压病情得到控制。进行了切开活检，随访7天后愈合完成。病例3，一名61岁男性，主诉软腭突然出现一个出血性水疱，已自行破裂。患者患有经治疗控制的全身性高血压。随访10天后溃疡愈合。病例4，一名49岁女性，主诉软腭疼痛和溃疡。患者报告在进餐期间迅速出现一个血疱，几分钟内破裂。14天后症状消失。出血性大疱性口炎似乎比文献报道的更为常见，了解这种疾病对于正确诊断和在必要时采取恰当的治疗方法很重要。
