Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, UK.
Arch Toxicol. 2011 Jan;85(1):59-66. doi: 10.1007/s00204-010-0536-6. Epub 2010 Apr 1.
This study examined the carcinogenic potential of di-isodecyl phthalate (DIDP) in rasH2 mice. DIDP was administered to 15 rasH2 mice/gender/group at dietary levels of 0, 0.1, 0.33, or 1% and 15 wild-type mice/gender/group at dietary levels of 0 and 1% for 26 weeks. Non-neoplastic changes were observed in the liver (parenchymal inflammation, fatty changes, diffuse hepatocyte hypertrophy with eosinophilic granules and focal necrosis) and kidneys (tubular basophilia and tubular hyperplasia) after administration of DIDP in the rasH2 and wild-type mice. In the neoplastic lesions, there were a higher number of hepatocellular adenomas in the male rasH2 mice receiving 1% DIDP, compared with the findings in the liver of control rasH2 mice or wild-type mice. The incidence of hepatocellular adenomas in the 0.1, 0.33, and 1% DIDP exposed rasH2 mice was 7% (1/15), 7% (1/15), and 33% (5/15), respectively. This study adds a set of results for an additional test chemical for the performance of the rasH2 short-term transgenic model to the existing database of 3 compounds (WY-14643, DEHP, and clofibrate) tested in the ILSI/HESI ACT project.
本研究检测了邻苯二甲酸二异葵酯（DIDP）在 rasH2 小鼠中的致癌潜力。将 DIDP 以 0、0.1、0.33 或 1%的饮食水平分别给予 15 只雄性/雌性 rasH2 小鼠/组和 15 只雄性/雌性野生型小鼠/组，持续 26 周。给予 DIDP 后，rasH2 小鼠和野生型小鼠的肝脏（实质炎症、脂肪变性、弥漫性肝细胞肥大伴嗜酸性颗粒和局灶性坏死）和肾脏（肾小管嗜碱性和肾小管增生）出现非肿瘤性变化。在接受 1% DIDP 处理的雄性 rasH2 小鼠的肿瘤病变中，肝细胞腺瘤的数量高于对照 rasH2 小鼠或野生型小鼠的肝脏。在 0.1%、0.33%和 1% DIDP 暴露的 rasH2 小鼠中，肝细胞腺瘤的发生率分别为 7%（1/15）、7%（1/15）和 33%（5/15）。本研究为 ILSI/HESI ACT 项目中测试的 3 种化合物（WY-14643、DEHP 和氯贝丁酯）的现有数据库增加了一组额外测试化学品的结果。
