Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2012 Jul;28(7 Suppl):S22-7. doi: 10.1016/j.kjms.2012.05.006. Epub 2012 Jul 10.
Phthalates--substances used in the manufacture of plastics--are considered as possible human carcinogens and tumor-promoting agents. The worldwide annual production of plastics surpassed 300 million tons in 2010. Plastics are an indispensable material in modern society, and many products manufactured from plastics are a boon to public health; however, plastics also pose health risks. Animal studies have indicated that phthalates are carcinogenic, but human epidemiological data confirming this carcinogenicity in humans are limited. The activation of peroxisome proliferator-activated receptor α (PPARα), which has been observed in rodent carcinogenesis, has not been observed in humans. Here, we review the hypothesis that the aryl hydrocarbon receptor (AhR) and its downstream signaling cascade promote phthalate-induced tumorigenesis.
邻苯二甲酸酯类物质（用于制造塑料的物质）被认为是可能的人类致癌物质和肿瘤促进剂。2010 年，全球塑料年产量超过 3 亿吨。塑料是现代社会不可或缺的材料，许多由塑料制成的产品对公众健康有益；然而，塑料也带来了健康风险。动物研究表明，邻苯二甲酸酯类物质具有致癌性，但证实人类致癌性的人类流行病学数据有限。在啮齿动物致癌作用中观察到的过氧化物酶体增殖物激活受体α（PPARα）的激活，在人类中并未观察到。在这里，我们回顾了芳基烃受体（AhR）及其下游信号级联促进邻苯二甲酸酯诱导肿瘤发生的假说。
