Department of Neurosurgery, University Hospital of Ioannia, Ioannina, Greece.
Neurol Neurochir Pol. 2010 Jan-Feb;44(1):80-6. doi: 10.1016/s0028-3843(14)60408-4.
This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.
本文主要关注位于 10 号染色体上的磷酸酶和张力蛋白同源物基因(PTEN)在恶性胶质瘤中的最新作用数据。PTEN 作为一种肿瘤抑制基因,在细胞周期进展、血管生成、迁移、侵袭和干细胞调节中发挥着关键作用。此外,它还与其他肿瘤抑制基因相互作用。我们讨论了 miRNAs 在调节 PTEN 表达中的作用,以及 PTEN 在核内的作用。