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ACE inhibitors in the elderly.

作者信息

Posvar E L, Sedman A J

机构信息

Parke-Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan.

出版信息

Angiology. 1991 May;42(5):387-96. doi: 10.1177/000331979104200506.

DOI:10.1177/000331979104200506
PMID:2035890
Abstract

As the population with hypertension becomes older, it is important to determine the properties of angiotensin-converting enzyme (ACE) inhibitors in the elderly. The pharmacokinetics and efficacy of captopril, enalapril, and a new once-daily ACE inhibitor, quinapril for the treatment of hypertension in young and elderly patients are reviewed, and the safety profiles of these agents in young and elderly patients are discussed. Although the safely profile of all three drugs is very favorable, quinapril tended to be better tolerated by patients of all ages in comparative clinical trials.

摘要

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引用本文的文献

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Optimal dosage of ACE inhibitors in older patients.老年患者中血管紧张素转换酶抑制剂的最佳剂量
Drugs Aging. 1996 Oct;9(4):262-73. doi: 10.2165/00002512-199609040-00004.
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The pharmacokinetics of quinapril and quinaprilat in patients with congestive heart failure.喹那普利和喹那普利拉在充血性心力衰竭患者中的药代动力学。
Br J Clin Pharmacol. 1994 Mar;37(3):302-4. doi: 10.1111/j.1365-2125.1994.tb04280.x.
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Quinapril hydrochloride effects on renal function in patients with renal dysfunction and hypertension: a drug-withdrawal study.盐酸喹那普利对肾功能不全合并高血压患者肾功能的影响：一项撤药研究。
Cardiovasc Drugs Ther. 1994 Apr;8(2):271-5. doi: 10.1007/BF00877336.
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