多巴胺受体 D4（DRD4）基因第 3 外显子 VNTR 多态性与墨西哥裔美国人酗酒的关联性。
The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans.
机构信息
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
出版信息
Psychiatry Res. 2010 May 30;177(3):358-60. doi: 10.1016/j.psychres.2010.02.021. Epub 2010 Apr 1.
Abstract
In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.
摘要
在这项研究中，对位于多巴胺受体 D4（DRD4）基因外显子 3 中的一个 48 碱基对序列的可变数串联重复（VNTR）多态性，在 365 名酗酒的和 337 名非酗酒的墨西哥裔美国人中进行了基因分型。逻辑回归显示，没有 7 个重复等位基因的基因型是酗酒的危险因素。然而，线性回归没有发现 DRD4 VNTR 与 MAXDRINKS 之间的关联，后者定义为 24 小时内消耗的最大饮料量。我们的结果表明，DRD4 VNTR 与墨西哥裔美国人的酗酒之间存在关联。
相似文献
1
The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans.多巴胺受体 D4（DRD4）基因第 3 外显子 VNTR 多态性与墨西哥裔美国人酗酒的关联性。
Psychiatry Res. 2010 May 30;177(3):358-60. doi: 10.1016/j.psychres.2010.02.021. Epub 2010 Apr 1.
2
Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts.MAOA 启动子和 DRD4 外显子 3 的 VNTR 多态性与男性中国吸毒者海洛因依赖的关联。
World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):409-16. doi: 10.3109/15622970903304459.
3
Association of the DRD4 exon III and 5-HTTLPR VNTR polymorphisms with substance abuse in Jordanian Arab population.DRD4 外显子 III 和 5-HTTLPR VNTR 多态性与约旦阿拉伯人群物质滥用的关联。
Gene. 2020 Apr 5;733:144267. doi: 10.1016/j.gene.2019.144267. Epub 2019 Dec 3.
4
Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients.墨西哥精神病患者中多巴胺D4受体基因座外显子III和外显子I多态性的关联分析。
Psychiatry Res. 2007 Dec 3;153(3):209-15. doi: 10.1016/j.psychres.2006.12.011. Epub 2007 Sep 5.
5
Effect of model choice in genetic association studies: DRD4 exon III VNTR and cigarette use in young adults.遗传关联研究中模型选择的影响：DRD4 外显子 III VNTR 与年轻人的吸烟行为。
Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):346-51. doi: 10.1002/ajmg.b.31169. Epub 2011 Jan 13.
6
The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects.多巴胺D受体（DRD4）基因外显子III多态性、问题性饮酒与寻求新奇感：直接和介导的遗传效应
Addict Biol. 2009 Apr;14(2):238-44. doi: 10.1111/j.1369-1600.2008.00120.x. Epub 2008 Aug 19.
7
[Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder].[多巴胺受体D4基因外显子III 48bp可变数目串联重复多态性与抽动障碍的传递不平衡检验]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Apr;19(2):100-3.
8
Self-Reported Sexual Behavioral Interests and Polymorphisms in the Dopamine Receptor D4 (DRD4) Exon III VNTR in Heterosexual Young Adults.异性恋年轻成年人中自我报告的性行为兴趣与多巴胺受体D4（DRD4）外显子III可变数目串联重复序列多态性
Arch Sex Behav. 2016 Nov;45(8):2091-2100. doi: 10.1007/s10508-015-0646-6. Epub 2015 Nov 18.
9
Haplotype and nucleotide variation in the exon 3-VNTR of the DRD4 gene from indigenous and urban populations of Mexico.墨西哥本土和城市人群中DRD4基因外显子3-VNTR的单倍型和核苷酸变异
Am J Hum Biol. 2014 Sep-Oct;26(5):682-9. doi: 10.1002/ajhb.22581. Epub 2014 Jun 30.
10
Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population.印度人群中多巴胺D4受体（DRD4）基因多态性与注意力缺陷多动障碍的关联
Am J Med Genet B Neuropsychiatr Genet. 2006 Jan 5;141B(1):61-6. doi: 10.1002/ajmg.b.30225.
引用本文的文献
1
Parsing out the role of dopamine D4 receptor gene (DRD4) on alcohol-related phenotypes: A meta-analysis and systematic review.解析多巴胺 D4 受体基因（DRD4）在酒精相关表型中的作用：一项荟萃分析和系统评价。
Addict Biol. 2020 May;25(3):e12770. doi: 10.1111/adb.12770. Epub 2019 May 31.
2
Ondansetron and sertraline may interact with 5-HTTLPR and DRD4 polymorphisms to reduce drinking in non-treatment seeking alcohol-dependent women: exploratory findings.昂丹司琼和舍曲林可能与5-羟色胺转运体基因启动子区域多态性（5-HTTLPR）及多巴胺D4受体基因（DRD4）多态性相互作用，以减少未寻求治疗的酒精依赖女性的饮酒量：探索性研究结果。
Alcohol. 2014 Sep;48(6):515-22. doi: 10.1016/j.alcohol.2014.04.005. Epub 2014 Aug 14.
3
Nur-related receptor 1 gene polymorphisms and alcohol dependence in Mexican Americans.Nur 相关受体 1 基因多态性与墨西哥裔美国人的酒精依赖。
World J Gastroenterol. 2012 Oct 7;18(37):5276-82. doi: 10.3748/wjg.v18.i37.5276.
本文引用的文献
1
The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: a review.多巴胺D4受体基因外显子3可变数目串联重复多态性与成瘾相关表型：综述
Pharmacol Biochem Behav. 2009 Sep;93(3):222-9. doi: 10.1016/j.pbb.2009.03.010. Epub 2009 Mar 29.
2
Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: results from a high-risk community sample.新奇寻求在介导多巴胺D4受体基因外显子III多态性与男性青少年酗酒之间的关联中所起的作用：来自高风险社区样本的结果
Biol Psychiatry. 2007 Jan 1;61(1):87-92. doi: 10.1016/j.biopsych.2006.05.025. Epub 2006 Aug 30.
3
Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds.15岁青少年中多巴胺D4受体与血清素转运体启动子多态性在烟酒使用方面的相互作用。
Neurogenetics. 2006 Nov;7(4):239-46. doi: 10.1007/s10048-006-0050-4. Epub 2006 Jul 4.
4
The human dopamine D4 receptor repeat sequences modulate expression.人类多巴胺D4受体重复序列调节表达。
Pharmacogenomics J. 2003;3(6):343-8. doi: 10.1038/sj.tpj.6500208.
5
Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits.人类多巴胺D4受体基因（DRD4）上游区域多态性与精神分裂症及人格特质的关联分析。
J Hum Genet. 2001;46(1):26-31. doi: 10.1007/s100380170120.
6
A genome screen of maximum number of drinks as an alcoholism phenotype.以最大饮酒量作为酒精中毒表型的基因组筛查。
Am J Med Genet. 2000 Oct 9;96(5):632-7. doi: 10.1002/1096-8628(20001009)96:5<632::aid-ajmg8>3.0.co;2-#.
7
The heritability of alcoholism symptoms: "indicators of genetic and environmental influence in alcohol-dependent individuals" revisited.酒精中毒症状的遗传度：再探“酒精依赖个体中基因与环境影响的指标”
Alcohol Clin Exp Res. 1999 May;23(5):759-69. doi: 10.1111/j.1530-0277.1999.tb04181.x.
8
Association between alcoholism and the dopamine D4 receptor gene.酗酒与多巴胺D4受体基因之间的关联。
J Med Genet. 1996 Feb;33(2):113-5. doi: 10.1136/jmg.33.2.113.
9
The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus.人类多巴胺D4受体基因座上等位基因频率的全球分布。
Hum Genet. 1996 Jul;98(1):91-101. doi: 10.1007/s004390050166.
10
Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism.慢性酒精中毒中D4多巴胺受体等位基因的多态性
Biochem Biophys Res Commun. 1993 Oct 15;196(1):107-14. doi: 10.1006/bbrc.1993.2222.
Zotero 插件