Falk R J, Jennette J C
Department of Medicine, University of North Carolina, Chapel Hill 27599.
Annu Rev Med. 1991;42:459-69. doi: 10.1146/annurev.me.42.020191.002331.
Systemic vasculitis is often difficult to diagnose. The recent discovery of a new class of autoantibodies [antineutrophil cytoplasmic autoantibodies (ANCA)] provides clinicians with a serological test that strongly supports the diagnosis of the most common forms of systemic necrotizing vasculitis. The spectrum of patients with this form of vascular inflammation ranges from those with renal-limited glomerulonephritis to patients with multisystem disease, including Wegener's granulomatosis and polyarteritis nodosa.
系统性血管炎常常难以诊断。最近发现的一类新的自身抗体[抗中性粒细胞胞浆自身抗体（ANCA）]为临床医生提供了一种血清学检测方法，有力地支持了对最常见形式的系统性坏死性血管炎的诊断。这种血管炎症形式的患者范围从仅有肾脏受累的肾小球肾炎患者到患有多系统疾病的患者，包括韦格纳肉芽肿病和结节性多动脉炎。
