“给予与获取”：胰岛中的内皮细胞和β细胞。

'Giving and taking': endothelial and beta-cells in the islets of Langerhans.

机构信息

Institute for Metabolic Physiology, Heinrich-Heine-University of Düsseldorf, Building 26.12. 00, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.

出版信息

Trends Endocrinol Metab. 2010 Aug;21(8):457-63. doi: 10.1016/j.tem.2010.03.003. Epub 2010 Mar 31.

DOI:10.1016/j.tem.2010.03.003

PMID:20359908

Abstract

The beta-cells of the islets of Langerhans are embedded in a dense capillary network. The blood vessels supply the islet cells with nutrients and oxygen, and in turn take up the secreted islet hormones to deliver them to target tissues. In addition, vessels provide a basement membrane, which optimizes islet function. In this review we focus on the dynamic interactions between blood vessels and beta-cells, which are pivotal for enhancing insulin expression and beta-cell proliferation in response to increased insulin demand during body growth, pregnancy, and virtually all conditions associated with insulin resistance. Importantly, a failure in this adaptive response might contribute to the onset of type 2 diabetes mellitus.

摘要

胰岛的β细胞嵌入在密集的毛细血管网络中。血管为胰岛细胞提供营养物质和氧气，反过来又吸收分泌的胰岛激素，将其输送到靶组织。此外，血管提供了基底膜，优化了胰岛的功能。在这篇综述中，我们重点讨论了血管和β细胞之间的动态相互作用，这对于增强胰岛素的表达和β细胞的增殖至关重要，因为这是对身体生长、妊娠以及几乎所有与胰岛素抵抗相关的情况下增加胰岛素需求的适应性反应。重要的是，这种适应性反应的失败可能导致 2 型糖尿病的发生。