Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322-3090, USA.
Neuroscientist. 2010 Aug;16(4):335-41. doi: 10.1177/1073858409357118. Epub 2010 Apr 1.
Autophagy is a term used to describe the process by which lysosomes degrade intracellular components. Known originally as an adaptive response to nutrient deprivation, autophagy has now been recognized to play important roles in several human disorders including neurodegenerative diseases. Experimental results from genetic, cellular, and toxicological studies indicate that many of the etiological factors associated with Parkinson disease (PD) can perturb the autophagic process in various model systems. Thus, the emerging data support the view that dysregulation of autophagy may play a critical role in the pathogenic process of PD.
自噬是一个用来描述溶酶体降解细胞内成分的过程的术语。自噬最初被认为是对营养缺乏的一种适应性反应，但现在已经被认识到在几种人类疾病中发挥着重要作用，包括神经退行性疾病。遗传、细胞和毒理学研究的实验结果表明，与帕金森病 (PD) 相关的许多病因因素可以在各种模型系统中扰乱自噬过程。因此，新出现的数据支持这样一种观点，即自噬的失调可能在 PD 的发病机制中起着关键作用。
